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2009/1/29

インフルエンザ、万能ワクチン開発

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※- インフルエンザ、万能ワクチン開発 -web news-
 
 ・厚労省研究班・
 
いろいろなタイプのインフルエンザウイルスに効くワクチンを厚生労働省研究班が開発した。
 
従来のワクチンと違い、ウイルスが変異しても効果が続くのが特徴で、動物実験で確かめた。
 
実用化までには数年かかるとみられるが、新型インフルエンザの予防にも役立つと期待される。
 
研究班は、国立感染症研究所、北海道大、埼玉医科大、化学メーカーの日油。
 
通常のワクチンは、ウイルス表面をとげのように覆うたんぱく質をもとに作る。
 
接種後、ウイルスが体内に侵入すると、抗体がとげを認識して増殖を阻止する。
 
だが、インフルエンザは、とげの形が異なる複数のウイルスが流行することが多いうえに、頻繁にとげの形が変異するため、毎年のようにワクチンを作り直す必要があった。
 
流行する型の予測がはずれると、ワクチン接種の効果が薄れた。
 
研究班は、表面に比べて変異しにくいウイルス内部のたんぱく質を人工合成。
 
それに特殊な脂質膜をくっつけてワクチンを作った。
 
このワクチンを接種すると、免疫細胞が、ウイルスの感染した細胞を攻撃する。
 
実験では、新型インフルエンザウイルスに変異する可能性が高い高病原性鳥インフルエンザウイルスH5N1、Aソ連型、A香港型の3種共通の内部たんぱく質を調べ、ワクチンを作製。
 
免疫に関与する人間の遺伝子を組み入れたマウスに接種した後、ウイルス3種をマウスに感染させても症状が表れず、増殖も抑えた。
 
ただ、これまでにないタイプのワクチンなので、人間に使って重い副作用が出ないか、慎重に確認する必要がある。
 
同じ仕組みのワクチンを英オックスフォード大も研究中という。
 
研究代表者の内田哲也・感染研主任研究官は「人間に有効で安全な量を調べ、一刻も早く実用化につなげたい」と話している
 
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2009/1/22

オバマ米新大統領・就任演説

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※- オバマ米国・新大統領の就任演説
 
 

My fellow citizens:

I stand here today humbled by the task before us, grateful for the trust you have bestowed, mindful of the sacrifices borne by our ancestors. I thank President Bush for his service to our nation, as well as the generosity and cooperation he has shown throughout this transition.

Forty-four Americans have now taken the presidential oath. The words have been spoken during rising tides of prosperity and the still waters of peace. Yet, every so often the oath is taken amidst gathering clouds and raging storms. At these moments, America has carried on not simply because of the skill or vision of those in high office, but because We the People have remained faithful to the ideals of our forbearers, and true to our founding documents.

So it has been. So it must be with this generation of Americans.

That we are in the midst of crisis is now well understood. Our nation is at war, against a far-reaching network of violence and hatred. Our economy is badly weakened, a consequence of greed and irresponsibility on the part of some, but also our collective failure to make hard choices and prepare the nation for a new age. Homes have been lost; jobs shed; businesses shuttered. Our health care is too costly; our schools fail too many; and each day brings further evidence that the ways we use energy strengthen our adversaries and threaten our planet.

These are the indicators of crisis, subject to data and statistics. Less measurable but no less profound is a sapping of confidence across our land - a nagging fear that America's decline is inevitable, and that the next generation must lower its sights.

Today I say to you that the challenges we face are real. They are serious and they are many. They will not be met easily or in a short span of time. But know this, America - they will be met.

On this day, we gather because we have chosen hope over fear, unity of purpose over conflict and discord.

On this day, we come to proclaim an end to the petty grievances and false promises, the recriminations and worn out dogmas, that for far too long have strangled our politics.

We remain a young nation, but in the words of Scripture, the time has come to set aside childish things. The time has come to reaffirm our enduring spirit; to choose our better history; to carry forward that precious gift, that noble idea, passed on from generation to

generation: the God-given promise that all are equal, all are free, and all deserve a chance to pursue their full measure of happiness.

In reaffirming the greatness of our nation, we understand that greatness is never a given. It must be earned. Our journey has never been one of short-cuts or settling for less. It has not been the path for the faint-hearted - for those who prefer leisure over work, or seek only the pleasures of riches and fame. Rather, it has been the risk-takers, the doers, the makers of things - some celebrated but more often men and women obscure in their labor, who have carried us up the long, rugged path towards prosperity and freedom.

For us, they packed up their few worldly possessions and traveled across oceans in search of a new life.

For us, they toiled in sweatshops and settled the West; endured the lash of the whip and plowed the hard earth.

For us, they fought and died, in places like Concord and Gettysburg; Normandy and Khe Sahn.

Time and again these men and women struggled and sacrificed and worked till their hands were raw so that we might live a better life. They saw America as bigger than the sum of our individual ambitions; greater than all the differences of birth or wealth or faction.

This is the journey we continue today. We remain the most prosperous, powerful nation on Earth. Our workers are no less productive than when this crisis began. Our minds are no less inventive, our goods and services no less needed than they were last week or last month or last year. Our capacity remains undiminished. But our time of standing pat, of protecting narrow interests and putting off unpleasant decisions - that time has surely passed. Starting today, we must pick ourselves up, dust ourselves off, and begin again the work of remaking America.

For everywhere we look, there is work to be done. The state of the economy calls for action, bold and swift, and we will act - not only to create new jobs, but to lay a new foundation for growth. We will build the roads and bridges, the electric grids and digital lines that feed our commerce and bind us together. We will restore science to its rightful place, and wield technology's wonders to raise health care's quality and lower its cost. We will harness the sun and the winds and the soil to fuel our cars and run our factories. And we will transform our schools and colleges and universities to meet the demands of a new age. All this we can do. And all this we will do.

Now, there are some who question the scale of our ambitions - who suggest that our system cannot tolerate too many big plans. Their memories are short. For they have forgotten what this country has already done; what free men and women can achieve when imagination is joined to common purpose, and necessity to courage.

What the cynics fail to understand is that the ground has shifted beneath them - that the stale political arguments that have consumed us for so long no longer apply. The question we ask today is not whether our government is too big or too small, but whether it works - whether it helps families find jobs at a decent wage, care they can afford, a retirement that is dignified. Where the answer is yes, we intend to move forward. Where the answer is no, programs will end. And those of us who manage the public's dollars will be held to account - to spend wisely, reform bad habits, and do our business in the light of day - because only then can we restore the vital trust between a people and their government.

Nor is the question before us whether the market is a force for good or ill. Its power to generate wealth and expand freedom is unmatched, but this crisis has reminded us that without a watchful eye, the market can spin out of control - and that a nation cannot prosper long when it favors only the prosperous. The success of our economy has always depended not just on the size of our Gross Domestic Product, but on the reach of our prosperity; on our ability to extend opportunity to every willing heart - not out of charity, but because it is the surest route to our common good.

As for our common defense, we reject as false the choice between our safety and our ideals. Our Founding Fathers, faced with perils we can scarcely imagine, drafted a charter to assure the rule of law and the rights of man, a charter expanded by the blood of generations. Those ideals still light the world, and we will not give them up for expedience's sake. And so to all other peoples and governments who are watching today, from the grandest capitals to the small village where my father was born: know that America is a friend of each nation and every man, woman, and child who seeks a future of peace and dignity, and that we are ready to lead once more.

Recall that earlier generations faced down fascism and communism not just with missiles and tanks, but with sturdy alliances and enduring convictions. They understood that our power alone cannot protect us, nor does it entitle us to do as we please. Instead, they knew that our power grows through its prudent use; our security emanates from the justness of our cause, the force of our example, the tempering qualities of humility and restraint.

We are the keepers of this legacy. Guided by these principles once more, we can meet those new threats that demand even greater effort - even greater cooperation and understanding between nations. We will begin to responsibly leave Iraq to its people, and forge a hard-earned peace in Afghanistan. With old friends and former foes, we will work tirelessly to lessen the nuclear threat, and roll back the specter of a warming planet. We will not apologize for our way of life, nor will we waver in its defense, and for those who seek to advance their aims by inducing terror and slaughtering innocents, we say to you now that our spirit is stronger and cannot be broken; you cannot outlast us, and we will defeat you.

For we know that our patchwork heritage is a strength, not a weakness. We are a nation of Christians and Muslims, Jews and Hindus - and non-believers. We are shaped by every language and culture, drawn from every end of this Earth; and because we have tasted the bitter swill of civil war and segregation, and emerged from that dark chapter stronger and more united, we cannot help but believe that the old hatreds shall someday pass; that the lines of tribe shall soon dissolve; that as the world grows smaller, our common humanity shall reveal itself; and that America must play its role in ushering in a new era of peace.

To the Muslim world, we seek a new way forward, based on mutual interest and mutual respect. To those leaders around the globe who seek to sow conflict, or blame their society's ills on the West - know that your people will judge you on what you can build, not what you destroy. To those who cling to power through corruption and deceit and the silencing of dissent, know that you are on the wrong side of history; but that we will extend a hand if you are willing to unclench your fist.

To the people of poor nations, we pledge to work alongside you to make your farms flourish and let clean waters flow; to nourish starved bodies and feed hungry minds. And to those nations like ours that enjoy relative plenty, we say we can no longer afford indifference to suffering outside our borders; nor can we consume the world's resources without regard to effect. For the world has changed, and we must change with it.

As we consider the road that unfolds before us, we remember with humble gratitude those brave Americans who, at this very hour, patrol far-off deserts and distant mountains. They have something to tell us today, just as the fallen heroes who lie in Arlington whisper through the ages. We honor them not only because they are guardians of our liberty, but because they embody the spirit of service; a willingness to find meaning in something greater than themselves. And yet, at this moment - a moment that will define a generation - it is precisely this spirit that must inhabit us all.

For as much as government can do and must do, it is ultimately the faith and determination of the American people upon which this nation relies. It is the kindness to take in a stranger when the levees break, the selflessness of workers who would rather cut their hours than see a friend lose their job which sees us through our darkest hours. It is the firefighter's courage to storm a stairway filled with smoke, but also a parent's willingness to nurture a child, that finally decides our fate.

Our challenges may be new. The instruments with which we meet them may be new. But those values upon which our success depends - hard work and honesty, courage and fair play, tolerance and curiosity, loyalty and patriotism - these things are old. These things are true. They have been the quiet force of progress throughout our history. What is demanded then is a return to these truths. What is required of us now is a new era of responsibility - a recognition, on the part of every American, that we have duties to ourselves, our nation, and the world, duties that we do not grudgingly accept but rather seize gladly, firm in the knowledge that there is nothing so satisfying to the spirit, so defining of our character, than giving our all to a difficult task.

This is the price and the promise of citizenship.

This is the source of our confidence - the knowledge that God calls on us to shape an uncertain destiny.

This is the meaning of our liberty and our creed - why men and women and children of every race and every faith can join in celebration across this magnificent mall, and why a man whose father less than sixty years ago might not have been served at a local restaurant can now stand before you to take a most sacred oath.

So let us mark this day with remembrance, of who we are and how far we have traveled. In the year of America's birth, in the coldest of months, a small band of patriots huddled by dying campfires on the shores of an icy river. The capital was abandoned. The enemy was advancing. The snow was stained with blood. At a moment when the outcome of our revolution was most in doubt, the father of our nation ordered these words be read to the people:

"Let it be told to the future world...that in the depth of winter, when nothing but hope and virtue could survive...that the city and the country, alarmed at one common danger, came forth to meet [it]."

America. In the face of our common dangers, in this winter of our hardship, let us remember these timeless words. With hope and virtue, let us brave once more the icy currents, and endure what storms may come. Let it be said by our children's children that when we were tested we refused to let this journey end, that we did not turn back nor did we falter; and with eyes fixed on the horizon and God's grace upon us, we carried forth that great gift of freedom and delivered it safely to future generations. 

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2009/1/13

イスラエル軍・ガザ人口密集地へ

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※- イスラエル軍・ガザ人口密集地へ進行
 
1月11日、パレスチナ自治区ガザへ侵攻しているイスラエル軍は、10日夜から11日にかけ、北部にあるガザ市近郊など人口密集地域の一部へも地上部隊が進行した。
 
イスラム原理主義組織ハマスの戦闘員と激しく交戦した。
 
先月の空爆開始後のパレスチナ人の死者は880人を超えた。
 

イスラエルのオルメルト暫定首相は11日の閣議で「我々は目標に近づいているが、到達にはさらに忍耐が必要だ」と述べて軍事作戦継続の意向を表明した。

イスラエル軍は10日夜以降に戦車や歩兵部隊がガザ市の南東部や北西部などに侵攻。

対戦車ミサイルなどで応戦するハマスと激しい戦闘となった。

空爆ではガザ全域で60カ所以上を攻撃した

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EUで寒波・死者約100人

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※- EUで寒波・死者約100人、ガス供給停止も響く
 
2009年、欧州では年明けから大寒波に見舞われ、100人弱の死者が出るなど深刻な影響が広がっている。
 
ドイツやポーランドなど西欧から中・東欧にかけて最低気温が零下30度に達する国が相次ぎ、温暖な地中海沿岸の南フランスでも積雪を記録した。
 
ロシア産天然ガスの供給停止問題も重なり、市民生活だけでなく、観光などにも影響が出ている。
 
ドイツ南部バイエルン州では9日未明に零下34.6度を記録。
 
ポーランドではホームレスなど約80人が凍死した。
 
スロバキアなどでも犠牲者が増えている。
 
地中海沿岸も寒波に見舞われ、避寒地であるスペインのマヨルカ島では10センチの積雪があった
 
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2009/1/2

パーキンソン病、早期診断

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※- パーキンソン病、早期診断に光 心臓の検査法を活用
 
手が震えたり、体の動きが不自由になったりする難病、パーキンソン病の診断に、心臓の神経密度の低下を調べる検査が使える可能性がある。
 
国立病院機構宇多野病院(京都市)と京都大学の研究グループが明らかにした。
 
早期診断や新しい治療法の研究に結びつきそうだ。
 
パーキンソン病患者は、国内で約10万人以上。脳の特定部分で神経細胞が減り、神経伝達物質が作れなくなって、体の動きが不自由になる。
 
脳の画像検査や血液検査には異常が出ず、症状が進むまで診断が難しい。
 
薬などで症状を抑えることはできるが、客観的な検査方法の確立や、発症前の診断、治療法の研究が課題となっていた。
 
グループは、パーキンソン病の疑いがある400人に特殊な放射線同位元素を静脈注射し、心臓の神経密度を画像化した。
 
その結果、心臓の神経が減っていた患者の9割以上がパーキンソン病だった。
 
この検査方法と、症状などによるこれまでの基準による診断結果を比べると、86%の患者で診断が一致したという。
 
グループの澤田秀幸・宇多野病院臨床研究部長は「発症前の早期診断ができるようになれば、神経細胞の減少を抑え、病気の発症を未然に防ぐ治療法開発の研究にもつながる」としている
 
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